Evolution of prostate cancer therapy. Part 1

Prostate cancer is the most common in men. Strategies relying on androgen deprivation have long been utilized it’s treatment. However, therapy of castration-resistant disease still remains challenging. Therapeu-tic options rapidly evolved during last decade. New molecules with unprecedented activity, provided significant survival benefit advanced disease. This review presents key aspects prostate systemic evolution over decades. The first part focuses therapies active Part two reviews data earlier lines and principles relevant to devising optimal treatment sequence.